The unfolded protein response signaling pathways in molluscs

Authors

  • Y Huang Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian 116023, China ; Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266235, China ; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian 116023, China
  • J Sun Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian 116023, China ; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian 116023, China
  • L Wang Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian 116023, China ; Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266235, China ; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian 116023, China
  • L Song Liaoning Key Laboratory of Marine Animal Immunology, Dalian Ocean University, Dalian 116023, China ; Laboratory of Marine Fisheries Science and Food Production Processes, Qingdao National Laboratory for Marine Science and Technology, Qingdao 266235, China ; Liaoning Key Laboratory of Marine Animal Immunology & Disease Control, Dalian Ocean University, Dalian 116023, China

DOI:

https://doi.org/10.25431/1824-307X/isj.v15i1.183-196

Keywords:

molluscs, unfolded protein response (UPR), signaling pathway, molecular components, expression profile, stress response

Abstract

Unfolded protein response (UPR) as collective signal transduction pathways is essential for
surviving the endoplasmic reticulum (ER) stress in vertebrates and invertebrates. Upon accumulation of unfolded proteins in the ER lumen, UPR increases the degradative and protein-folding capacities of cells and decreases global protein synthesis to maintain the cell homeostasis. Because of their importance in cellular stress and protein folding process, UPR signaling pathways receive increasing attentions, and their components and multiple regulation functions have been well characterized in mammals, fly, and worm etc. Molluscs are widely distributed in various environments with high species diversity, which exhibit remarkable capacity for adaptation and survival upon diverse stressors. Because of the homeostatic role in response to ER stress, the knowledge about UPR would be helpful for understanding the wide distributions, living habits and adaptability to the environment of molluscs. This review summarizes the UPR signaling pathways in molluscs with the emphasis on recent research progresses about the characteristics of molluscan UPR signaling pathway members and their expression profiles in response to various environmental stressors.

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Published

2018-05-14

Issue

Vol. 15 No. 1 (2018)

Section

Review